Ari Zimran Selected Research

Glucosylceramidase (Glucocerebrosidase)

1/2022	Gaucher Disease Diagnosis Using Lyso-Gb1 on Dry Blood Spot Samples: Time to Change the Paradigm?
1/2022	Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.
1/2018	UPR activation and CHOP mediated induction of GBA1 transcription in Gaucher disease.
1/2018	Trio approach reveals higher risk of PD in carriers of severe vs. mild GBA mutations.
11/2017	Exploring the patient journey to diagnosis of Gaucher disease from the perspective of 212 patients with Gaucher disease and 16 Gaucher expert physicians.
1/2017	Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data.
1/2017	Reductions in glucosylsphingosine (lyso-Gb1) in treatment-naïve and previously treated patients receiving velaglucerase alfa for type 1 Gaucher disease: Data from phase 3 clinical trials.
11/2016	New Directions in Gaucher Disease.
7/2015	Seven-year safety and efficacy with velaglucerase alfa for treatment-naïve adult patients with type 1 Gaucher disease.
3/2015	The emergence of Parkinson disease among patients with Gaucher disease.

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Ari Zimran Research Topics

Disease

133	Gaucher Disease (Gaucher's Disease) 01/2022 - 01/2002
10	Thrombocytopenia (Thrombopenia) 12/2020 - 01/2002
9	Parkinson Disease (Parkinson's Disease) 01/2021 - 02/2005
7	Anemia 12/2020 - 01/2002
7	Pain (Aches) 10/2020 - 01/2002
6	Splenomegaly 12/2020 - 08/2012
5	Necrosis 10/2016 - 08/2003
4	Hemorrhage 01/2022 - 02/2004
4	Osteonecrosis (Kienbock's Disease) 03/2020 - 08/2003
4	Hepatomegaly 03/2018 - 05/2010
4	Osteoporosis 10/2016 - 01/2004
4	Tremor (Tremors) 09/2014 - 05/2003
4	Hypersensitivity (Allergy) 02/2013 - 01/2009
4	Inflammation (Inflammations) 03/2010 - 01/2005
4	Pulmonary Hypertension 06/2007 - 08/2003
3	Fatigue 10/2020 - 06/2012
3	Hypersplenism (Anemia, Splenic) 04/2018 - 01/2002
3	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2018 - 11/2005
3	Spontaneous Abortion (Miscarriage) 05/2011 - 02/2004
3	Bone Diseases (Bone Disease) 01/2011 - 08/2007
2	Parkinsonian Disorders (Parkinsonism) 01/2020 - 06/2011
2	Metabolic Diseases (Metabolic Disease) 01/2018 - 12/2014
2	Clinical Deterioration 01/2016 - 07/2015
2	Tay-Sachs Disease 04/2015 - 01/2012
2	Body Weight (Weight, Body) 12/2014 - 02/2013
2	Cognitive Dysfunction 09/2014 - 02/2005
2	Chronic Disease (Chronic Diseases) 06/2012 - 02/2005
2	Neoplasms (Cancer) 01/2011 - 10/2009
2	Peripheral Nervous System Diseases (PNS Diseases) 10/2007 - 05/2003
2	Lung Diseases (Lung Disease) 06/2007 - 08/2003
2	Infections 02/2004 - 06/2002
1	Synucleinopathies 01/2022
1	Postpartum Hemorrhage 01/2021
1	Cough 01/2021
1	Respiratory Tract Diseases (Respiratory Tract Disease) 12/2020
1	Hepatitis A (Hepatitis, Infectious) 12/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2020
1	Ganglion Cysts (Ganglion) 09/2020
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2020
1	Neurologic Manifestations (Neurological Manifestations) 09/2019
1	Wandering Spleen 04/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018
1	Liver Diseases (Liver Disease) 01/2018
1	Iron Overload 01/2018
1	Disease Progression 04/2016
1	Dementia (Dementias) 04/2016
1	Aneuploidy (Aneuploid) 10/2015
1	Gastroenteritis 01/2015
1	Large Granular Lymphocytic Leukemia 12/2014
1	Missed Abortion 04/2014

Drug/Important Bio-Agent (IBA)

27	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022 - 01/2003
21	imiglucerase FDA Link 01/2020 - 01/2007
18	EnzymesIBA 01/2022 - 07/2002
11	Glucosylceramides (Glucocerebrosides)IBA 12/2020 - 05/2003
11	Biomarkers (Surrogate Marker)IBA 09/2020 - 05/2005
10	taliglucerase alfaIBA 01/2020 - 11/2011
8	Pharmaceutical PreparationsIBA 01/2021 - 02/2005
7	sphingosyl beta-glucosideIBA 07/2021 - 01/2013
6	Ambroxol (Mucosolvan)IBA 01/2021 - 02/2013
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2003
5	AcidsIBA 01/2022 - 11/2005
5	chitotriosidaseIBA 01/2021 - 07/2005
5	Hemoglobins (Hemoglobin)IBA 03/2018 - 08/2002
5	LipidsIBA 01/2017 - 01/2002
5	miglustat (Zavesca)FDA Link 08/2013 - 03/2002
4	eliglustatIBA 01/2019 - 10/2014
3	AntibodiesIBA 01/2016 - 01/2009
3	alglucerase FDA Link 09/2014 - 02/2009
3	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2011 - 01/2010
2	SynucleinsIBA 01/2022 - 09/2014
2	GlycosphingolipidsIBA 12/2020 - 09/2020
2	Indicators and Reagents (Reagents)IBA 04/2016 - 08/2003
2	Immunoglobulin G (IgG)IBA 01/2016 - 11/2011
2	GlucosidasesIBA 12/2014 - 05/2011
2	Lysergic Acid Diethylamide (LSD)IBA 01/2013 - 01/2012
2	Prostaglandins DIBA 01/2012 - 01/2011
2	methyl 4-azidophenylacetimidate (APAI)IBA 01/2011 - 01/2010
2	Brain Natriuretic Peptide (Natrecor)FDA Link 05/2005 - 01/2004
2	C-Reactive ProteinIBA 05/2005 - 01/2005
2	pro-brain natriuretic peptide (1-76)IBA 05/2005 - 01/2004
1	IntegrinsIBA 01/2022
1	P-SelectinIBA 01/2022
1	Expectorants (Mucolytics)IBA 01/2021
1	Retinaldehyde (Retinal)IBA 09/2020
1	Investigational DrugsIBA 01/2017
1	Levodopa (L Dopa)FDA LinkGeneric 04/2016
1	DNA (Deoxyribonucleic Acid)IBA 10/2015
1	Hexosaminidases (Hexosaminidase)IBA 04/2015
1	Biological ProductsIBA 12/2014
1	GD3 ganglioside (GD(3))IBA 09/2014

Therapy/Procedure

61	Enzyme Replacement Therapy 01/2022 - 01/2002
27	Therapeutics 07/2021 - 03/2002
11	Enzyme Therapy 08/2012 - 09/2002
9	Splenectomy 04/2018 - 01/2002
4	Arthroplasty 04/2014 - 12/2004
2	Hip Replacement Arthroplasty (Total Hip Replacement) 03/2020 - 03/2009
2	Drug Tapering 06/2011 - 05/2003
1	Minimally Invasive Surgical Procedures 04/2018
1	Intravenous Infusions 01/2018
1	Fluid Therapy (Oral Rehydration Therapy) 01/2015